ACTIV Preclinical Working Group: Small Animal Model Field Guide and Video Sessions

The small animal model videos are a compendium of world expert guidance on best practices for the use of small animal models for COVID 19 research. The videos were developed in an effort to support harmonization of best practices for the use of small animal models. This effort has been led by the Accelerating COVID-19 Therapeutic Interventions and Vaccines (ACTIV) partnership, a public-private partnership between NIH and the Foundation for NIH (FNIH).

Since SARS-COV-2 was first reported in late 2019, researchers around the world shifted gears to conduct COVID-19 studies. However, limited resources, including BSL 3 /4 facilities and COVID-19 animal models, have prompted an effort to harmonize and streamline guidance to make the best use of available biomedical research resources and facilitate interpretation and comparison of the results across studies. Using the Small Animal Model Field Guide and these videos as a guide, researchers will be able to improve harmonization and make the best use of available biomedical research resources.

ACTIV Small Animal Models Field Guide

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ACTIV Small Animal Models Video Sessions

Click on the speaker’s name to see each presentation

  • Virus Characteristics: Choosing a strain, passaging and sequencing
  • Foundational Practices for Small Animal Models – Mouse, Hamster and Ferret Models
    • Mouse Models
    • Hamster Models
  • In-life and Post-Mortem Measurements

Virus Characteristics: Choosing a strain, passaging and sequencing

Adolfo Garcia-Sastre: Virus strain selection and use for COVID-19 Research


Foundational Practices for Small Animal Models – Mouse, Hamster and Ferret Models

Mouse Models

Joanne Turner: Transgenic Mouse Models for COVID-19 Research

Ralph Baric: Mouse-Adapted Viruses for COVID-19 Research

Hamster Models

Phil Santangelo: Hamster Models for COVID-19 Research

Johan Neyts: Hamster Models for COVID-19 therapeutics research

Adam Werts: Lessons Learned from COVID-19 Hamster Drug Studies

Ferret Models

Adolfo Garcia-Sastre: Ferret Models for COVID-19 Research


In-life and Post-Mortem Measurements

Joanne Turner

Paul McCray

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