Accelerating Medicines Partnership – Type 2 Diabetes Project

Advancing treatments for Type 2 Diabetes by integrating patient data on a common platform for wider sharing and more rigorous analysis

The Problem
Researchers studying and attempting to treat Type 2 Diabetes have long lacked the tools needed to identify the genes responsible for the disease, as well as to identify and validate drug targets to treat it.
The Solution
AMP Type 2 Diabetes has established a publicly available Knowledge Portal that houses data from millions of Type 2 Diabetes patients and provides analytical tools that researchers can use to identify genes of interest and validate drug targets.

Overview

The Accelerating Medicines Partnership Type 2 Diabetes Project (AMP T2D) is a precompetitive partnership among government, industry and nonprofit organizations that harnesses the collective capabilities, scale and resources to improve current efforts to develop new therapies for complex, heterogeneous diseases, such as diabetes and diabetic complications. To date, the AMP T2D project has:

1) amassed, integrated and harmonized genetic and genomic data from existing cohorts from over 1.5 million individuals and made them publicly accessible for querying;

2) connected the data from over 230 phenotypes related to type 2 diabetes and metabolic complications and generated new genomic and target annotation data;

3) built a sophisticated and powerful Type 2 Diabetes Knowledge Portal that enables the broader scientific community and the public to access the data; and

4) developed advanced analytic tools that allow users to perform queries and test hypotheses to prioritize therapeutic targets. 

Since its launch in 2014, the AMP T2D Knowledge Portal has become the go-to source for researchers to deposit large amounts of diabetes and complications data for published studies (newly deposited data are curated and harmonized for querying alongside preexisting data). From 2019 to 2020, to accelerate the growth of the AMP T2D database, the program funded thirteen additional proposals. The 5-year, $58M project has been extended until 2021.

Visit the Knowledge Portal and access data and tools here.

Read a program overview on the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) website here.

Read the full project plan here.

Follow the latest development on the Knowledge Portal blog.

Partners

Private-Sector Partners

  • American Diabetes Association*
  • Eli Lilly and Company*
  • Janssen Research and Development LLC*
  • Juvenile Diabetes Research Foundation*
  • Merck Sharp & Dohme Corp.*
  • Pfizer Inc.*
  • Sanofi US Services*

*Provided financial or in-kind support for this program.

FNIH Contact

For additional information please contact Tania Kamphaus, Scientific Program Manager, at Tkamphaus@fnih.org or (301) 435-6247.