Our mission is to understand the biology of complex autoimmune disorders to enable better treatments for patients.

The Accelerating Medicines Partnership® (AMP®) Program Rheumatoid Arthritis (RA), Systemic Lupus Erythematosus (SLE) & Related Autoimmune Disorders project focused on molecular analyses of gene expression and signaling in specific subsets of immune cells and resident tissue cells, in RA patients’ synovium and blood and in lupus patients’ kidney biopsy, skin and blood. AMP RA/SLE used novel technologies to molecularly deconstruct and analyze these highly refined relevant cell subsets or single cells, in order to understand the mechanisms of disease.

One of the first three projects in the AMP portfolio, AMP RA/SLE formally closed in 2023. Building on the success of AMP RA/SLE, the initiative was expanded to investigate other autoimmune and immune-mediated diseases through the AMP AIM project in December 2021.

Results + Accomplishments
  • Assembled a comprehensive data set using a wide range of molecular technologies applied to small tissue biopsies, as well as urine and blood.

  • Developed novel approaches for precision medicine and disease “deconstruction.”

  • Developed computational strategies to analyze and interpret large-scale single cell data.

  • Discovered novel cellular populations essential to tissue inflammation in the kidney and the synovium, including inflammatory fibroblasts.

  • Defined clinical biomarkers for disease progression, severity and treatment in blood and tissue.

Biologically Complex Diseases

Autoimmune disorders such as Rheumatoid Arthritis and System Lupus Erythematosus are biologically complex. Understanding the underlying causes of these conditions is critical to treating them effectively.

Enabling Better Treatments

AMP RA/SLE investigated the biological processes that underline autoimmune disorders such as Rheumatoid Arthritis and Systemic Lupus Erythematosus to facilitate the development of more effective treatments.

Partners

Private Sector Partners
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Public Sector Partners
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Data Portals

National Library of Medicine’s Database of Genotypes and Phenotypes

Genotype and Phenotype data from AMP RA/SLE are available through the National Library of Medicine’s database of Genotypes and Phenotypes (dbGaP), accession: phs001457. v1. p1.

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ImmPort

Additional AMP RA/SLE data is available through ImmPort, accession: SDY998, SDY999

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