Our mission is to prioritize targets for type 2 diabetes and its complications.
The Accelerating Medicines Partnership® (AMP®) Program Type 2 Diabetes (AMP T2D) was a precompetitive partnership among government, industry, and nonprofit organizations that harnessed the collective capabilities, scale, and resources to improve current efforts to develop new therapies for complex heterogeneous diseases, such as diabetes and diabetic complications.
One of the first three projects in the AMP portfolio, AMP T2D was managed by the FNIH from 2014-2021. Building on the success of AMP T2D, the initiative was expanded to investigate other common metabolic diseases through the AMP CMD project in May 2021.
Major Unmet Medical Need
While there were a number of type 2 diabetes therapies on the market, no therapy had shown to achieve long-term reversal of the progression of hyperglycemia, or to prevent complications. Given the complex and intersecting pathways that control glucose homeostasis and energy balance, and the lack of clinical validity of existing cell and animal models, validation of drug targets for type 2 diabetes had remained challenging.
Harnessing Human Genetics
A promising approach was to take advantage of human genetics to validate drug targets. Literature had shown that by examining variants that affect type 2 diabetes and related phenotypes, researchers could unveil relevant mechanisms and pathways to validate drug targets. Therefore, the AMP T2D project explored human genetics as an approach to validate targets by exploiting experiments in nature that perturb protein functions.
Private Sector Partners
Public Sector Partners
T2D Knowledge Portal
The Type 2 Diabetes Knowledge Portal provides annotated and searchable genetic and genomic data from over 1.5 million individuals with type 2 diabetes.
International diabetes research knowledge portal opens to public, scientistsNIH News Release
Tania Kamphaus, M.Sc., Ph.D.
Director, Metabolic Disorders[email protected]
Lynette Nguyen, Ph.D., PMP
Senior Scientific Project Manager[email protected]
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