The goal of ACTIV is to develop a research strategy for prioritizing and speeding development of the most promising COVID-19 vaccines and treatments.


The Preclinical Working Group is focused on:

  • Establishing a centralized process and repository for harmonizing and sharing methods and evaluating animal models
  • Extending access to high-throughput screening facilities, especially in biosafety level 3 (BSL-3) labs
  • Increasing access to validated animal models
  • Enhancing comparison of approaches to identify informative assays
  • Generating a process to assess viral variant effects on vaccines and therapeutics

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TRACE  Initiative

The Tracking Resistance and Coronavirus Evolution (TRACE) initiative is focused on:

  • Monitoring global emergence and circulation of SARS-CoV-2 mutations
  • Cross-referencing initial sequence data against database of experimentally or clinically phenotyped mutants
  • Characterizing prioritized mutants in vitro through critical-path assays
  • Characterizing prioritized mutants in vivo through critical-path assays
  • Rapidly sharing activity data with ACTIV and scientific community

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"Long COVID” Seminar Series

The ACTIV Preclinical Working Group, in partnership with the National Heart, Lung, and Blood Institute (NHLBI), hosted an expert-led seminar series on post-acute sequelae of SARS-CoV-2 infection (PASC), also known as long COVID.