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Displaying 126 - 150 of 191

Biomarkers Consortium – Osteoarthritis Biomarkers Project
The Problem In knee osteoarthritis clinical trials, the traditional measure used to predict a patient’s disease progression and response ...
Biomarkers Consortium – Placebo Data Analysis Project in Alzheimer’s Disease/Mild Cognitive Impairment Clinical Trials
Overview The Biomarkers Consortium’s Placebo Data Analysis Project in Alzheimer’s Disease/Mild Cognitive Impairment Clinical Trials com...
Biomarkers Consortium – Plasma Aβ and Phosphorylated Tau as Predictors of Amyloid and Tau Positivity in Alzheimer’s Disease
The Problem Early treatment of Alzheimer’s disease requires early diagnosis. Yet available methods to diagnose early AD are expensive or ...
Biomarkers Consortium – PROGRESS OA: Clinical Evaluation and Qualification of Osteoarthritis Biomarkers
Overview The Biomarkers Consortium’s PROGRESS OA - Clinical Evaluation and Qualification of Osteoarthritis Biomarkers Project is the seco...
Remote Digital Monitoring and Patient-Centric Medical Product Development
Join us on June 24th and 25th for a collaborative workshop that brings together industry leaders, regulatory bodies, researchers, and patien...
Biomarkers Consortium – The Autism Biomarkers Consortium for Clinical Trials (ABC-CT)
The Problem Interventions for social impairments in children with autism are complicated by the heterogeneity of the disease and hampered b...
Biomarkers Consortium – The Performance of Novel Cardiac Biomarkers in the General U.S. Population
The Problem Cardiovascular disease is one of the most lethal conditions in the United States, yet Researchers lack the tools needed to asse...
Biomarkers Consortium – Use of Targeted Multiplex Proteomic Strategies to Identify CSF-Based Biomarkers in Alzheimer’s Disease
The Problem Early diagnosis of Alzheimer’s disease can improve clinicians’ ability to track the progression of the disease and to treat ...
Biomarkers Consortium – Use of Targeted Multiplex Proteomic Strategies to Identify Plasma-Based Biomarkers in Alzheimer’s Disease
Overview The lack of tools for early diagnosis and disease progression in Alzheimer’s disease (AD) continues to be a major hurdle in AD d...
Biomarkers Consortium – Vol-PACT: Advanced metrics and modeling with Volumetric CT for Precision Analysis of Clinical Trial results
    Overview This project was completed in August 2016. After the investment of millions of dollars and the involvement of thousa...
Biomarkers Consortium – Workshop: Defining an Evidentiary Criteria Framework for Surrogate Endpoint Qualification
Overview The Foundation for the National Institutes of Health (FNIH) Biomarkers Consortium, in partnership with the Food and Drug Administr...
Biomarkers Consortium – Workshop: Developing an Evidentiary Criteria Framework for Safety Biomarkers Qualification
The Problem The lack of standard assessment criteria makes it difficult for FDA to consistently evaluate the safety of the wide variety o...
Biomarkers Consortium – Clinical Evaluation and Qualification of Translational Kidney Safety Biomarkers
The Problem When conducting clinical trials of any drugs that could cause acute kidney injury, Researchers need biomarkers that can detect ...
African Centers of Excellence in Bioinformatics
The African Centers of Excellence in Bioinformatics is a strategic public-private partnership of the National Institute of Allergy and Infec...
Age-Related Eye Disease Study 2 (AREDS2) Ancillary Study
Overview The project was completed in 2013. The Age-Related Eye Disease Study 2 (AREDS2) overseen by the National Eye Institute (NEI) examin...
Alzheimer’s Disease Neuroimaging Initiative 2
Overview This program completed in August 2016. The Alzheimer’s Disease Neuroimaging Initiative (ADNI) is a landmark partnership and s...
Alzheimer’s Disease Neuroimaging Initiative 3 (ADNI 3)
The Problem Individuals with Alzheimer’s disease often do not show symptoms during the early stages of disease, limiting clinicians’ ab...
Amgen Scholars Program at NIH
Amgen Scholars Program at NIH" In 2015, the NIH became one of 24 leading institutions taking part in the Amgen Scholars Prog...
Baby Connectome Project
Overview The Baby Connectome Project (BCP) is a four-year study of children from birth through five years of age, intended to provide a bet...
Biomarkers Consortium – Bone Quality Project
The Problem Patients with osteoporosis, other bone diseases or increased risk for bone fractures have diminished bone strength and quality,...
Biomarkers Consortium – Carotid MRI Development and Validation via an AIMHIGH Sub-Study
Overview The Carotid MRI Reproducibility Study is a sub-study of a NHLBI-managed trial, called AIM HIGH. The goal of this project was to con...
Biomarkers Consortium – Chemotherapeutic Impact on the Immune MicroEnvironment
The Problem Innovative cancer therapies that activate patients’ immune systems against the disease have demonstrated the ability to improv...
Biomarkers Consortium – Developing Endpoints for Clinical Trials in Community Acquired Bacterial Pneumonia (CABP) and Acute Skin and Skin Infections (ABSSSI)
The Problem To develop effective treatments for community-acquired bacterial pneumonia and acute bacterial skin and skin structure infectio...
Biomarkers Consortium – Diabetes Drug Development: Identification and Validation of Markers That Predict Long-Term Beta Cell Function and Mass
The Problem Some patients with diabetes show dysfunction and diminishment of so-called “beta cells,” which can result in serious health ...
Biomarkers Consortium – Establish Guidelines for Initial Diagnostic Criteria for “Sarcopenia with Clinically Important Weakness” and Associated Evidence for Treatment Benefit
Overview This project completed in June 2010 The Sarcopenia 1 project launched in 2010 and aimed to establish the first evidence-based def...

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