Our mission is to protect laboring mothers and newborns against neonatal and maternal sepsis and death
The Azithromycin Prevention in Labor Use Study (A-PLUS) assessed low-cost, sustainable interventions to improve maternal and child health. A-PLUS researchers examined the safety and effectiveness of a single oral dose of intrapartum azithromycin compared to placebo (both in addition to standard of care) in reducing the risk of neonatal and maternal sepsis or death in laboring women. The results were positive, showing that azithromycin reduced the occurrence of sepsis and death by approximately a third.
As a next step, the A-PLUS investigators hope to enable a change to the current standard of care by adding this simple preventive intervention. This large study has great potential to inform and update the World Health Guidelines (WHO) to improve the outcomes of laboring mothers globally.