Comprehensive Cellular Vaccine Immune Monitoring Consortium

A collaborative program that provides standardized and research level assays for clinical and pre-clinical HIV vaccine trials.

The Problem
The development of a safe and broadly effective vaccine against HIV/AIDS has been elusive and, despite decades of effort, even the immunological responses that may lead to protective immunity remain largely undefined.
The Solution
This program will provide standardized and reproducible immunological measurements from clinical and pre-clinical trials and share assay data to elucidate correlates of protection and inform HIV vaccine design strategies.

Overview

The Comprehensive Cellular Vaccine Immune Monitoring Consortium (CCVIMC) provides centralized resources to the Collaboration for AIDS Vaccine Discovery (CAVD), for the development and licensure of a safe and broadly effective vaccine to HIV. The CCVIMC convenes leading scientists to develop, optimize and standardize cellular-immune assays for use in evaluating vaccine platforms being developed within the CAVD. Initiated in 2006, the current five-year grant focuses on expanding the consortium’s cellular immune monitoring capabilities by applying cutting-edge technologies to encompass the assessment of both T and B cell immune responses. Beyond providing exploratory, qualified and standardized cellular assays, the CCVMC also consults with vaccine-discovery laboratories to assist them in designing pre-clinical and clinical trials and provides systems biology analysis to their trial data. Scientific leadership is provided by the consortium’s Principal Investigator (PI), Richard Koup (NIAID), and administration and management of the program is directed by the FNIH.

Partners

  • Duke University
  • Fred Hutchinson Cancer Research Center
  • National Institute of Allergy and Infectious Diseases

Contact

Results & Accomplishments

Supporting AIDS Vaccine Development

The Comprehensive Cellular Vaccine Immune Monitoring Consortium has been providing high-quality cellular immune monitoring to the Collaboration for AIDS Vaccine Development (CAVD) for more than 14 years.

For CAVD study results, click here

 

For more information: https://www.cavd.org/grantees/Pages/Grantee-Koup.aspx