The NIH Undiagnosed Diseases Program


The NIH Undiagnosed Diseases Program (UDP) is part of the Undiagnosed Disease Network, an NIH Common Fund initiative that focuses on the most puzzling medical cases referred to the NIH Clinical Center. It was organized by the National Human Genome Research Institute (NHGRI), the NIH Office of Rare Diseases Research, and the NIH Clinical Center.

A longstanding medical condition that eludes diagnosis by a referring physician can be considered undiagnosed and may be of interest to this clinical research program. Of the total number of cases that are referred to this program, a very limited number will be invited to proceed in the study following careful application review by the program’s medical team. In general, it takes 8 to 12 weeks for the UDP to evaluate an application, and the waiting list for admission is 2 to 6 months.

The Undiagnosed Diseases Program pursues two goals:

  • To provide answers to patients with mysterious conditions that have long eluded diagnosis
  • To advance medical knowledge about rare and common diseases

For information, view Frequently Asked Questions.

Recent News: Undiagnosed Diseases Program brings hope to patients with perplexing conditions 


To donate, please contact [email protected] or visit our FNIH donation page.


Public-Sector Partners:

  • National Human Genome Research Institute (NHGRI)
  • NIH Office of Rare Diseases Research (ORDR)
  • NIH Clinical Center (CC)

Private-Sector Partners:

  • Individual donors

FNIH Contact

Please contact the Advancement Office for more information at [email protected] or 301-451-8855.

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