Research Programs

Heart Disease

The Moderate Alcohol and Cardiovascular Health Trial (MACH15) is a longitudinal, international clinical trial to determine the effects of moderate alcohol use on cardiovascular disease and diabetes.

Infectious Diseases

The Biomarkers Consortium’s Developing Endpoints for Clinical Trials in CABP and Skin Infections aims to develop approaches that will help the U.S. Food and Drug Administration develop efficacy outcome measures (endpoints) for modern-day clinical trials of investigational agents for community-acquired bacterial pneumonia (CABP) and acute bacterial skin and skin structure infections (ABSSSI).

Infectious Diseases

The Centralized Envelope Comparative Immunogenicity Study is an HIV/AIDS vaccine development project that seeks to answer a central question that has blocked the development of a successful HIV vaccine: how can we design vaccine immunogens that address the broad genetic diversity of HIV?

Infectious Diseases

A collaborative program that provides standardized and research level assays for clinical and pre-clinical HIV vaccine trials.

Infectious Diseases

This project will provide consensus recommendations for field testing mosquitoes modified with driving transgenes as a tools for preventing malaria transmission in Africa.

Infectious Diseases

This program is field testing a new self-sustaining biocontrol technology to prevent transmission of dengue, zika and chikungunya viruses by vector mosquitoes.

Infectious Diseases

In India, the sand fly vector Phlebotomus argentipes is responsible for the transmission of the protozoan parasite Leishmania donovani, which causes a disease called visceral leishmaniasis (VL), fr

Infectious Diseases

The study was implemented using shared and harmonized protocols across the eight sites to gather an enormous amount of data (physical, cognitive assessments, diet, illness and enteric infection, socio-economic status, etc.) to enable identification and characterization of factors associated with negative impacts on a child’s growth, development and vaccine response early in life.

Infectious Diseases

To produce high-quality chemical hit series with defined, tractable targets as drug leads for tuberculosis.

Infectious Diseases

PredictTB is a five-year clinical trial project that aims to shorten the treatment times of tuberculosis (TB) in drug-sensitive patients through individualized therapy.