To tackle the human health challenges that face the world today, the FNIH develops collaborations with top experts from government, industry, academia and the not-for-profit sector and provides a neutral environment where we can work productively toward a common goal.
Two billion people worldwide are infected with Mycobacterium tuberculosis (Mtb) resulting in 10 million cases of clinical disease and 1.5 million deaths each year. The hurdles for developing a highly protective and durable vaccine against Mtb require addressing four central tenets of T cell immunology – magnitude, quality, breadth, and location of the response. These specific elements of the problem will be addressed by focusing on how altering the route of vaccination using a whole attenuated organism vaccine substantially increases immune responses and protection in a rigorous non-human primate model of Mtb infection.
A collaborative program that provides standardized and research level assays for clinical and pre-clinical HIV vaccine trials.
SHORTEN-TB will build on lessons learned from the HIT-TB program to identify leads that have the greatest potential to comprise drug regimens that will significantly reduce the duration of chemotherapy for tuberculosis.
PredictTB is a five-year clinical trial project that aims to shorten the treatment times of tuberculosis (TB) in drug-sensitive patients through individualized therapy.
The Jayne Koskinas Ted Giovanis (JKTG) Foundation for Health and Policy established two NIH Intramural Research Training Awards (IRTAs) for deserving young scholars in the NIH Intramural Training program. Through this IRTA, the JKTG Foundation aims to fund fellows whose basic research could help to expand the understanding of disease and could ultimately result in clinical applications.
The Roth Fellowship for CAEBV-HV Research was established to support a fellowship in the lab of Jeffrey I. Cohen, M.D., Chief of the Laboratory of Infectious Diseases and Chief of the Medical Virology Section at the National Institute of Allergy and Infectious Diseases (NIAID).
In India, the sand fly vector Phlebotomus argentipes is responsible for the transmission of the protozoan parasite Leishmania donovani, which causes a disease called visceral leishmaniasis (VL), from one human to another.
To identify host- and parasite-specific biomarker(s) present in human subjects with viable adult females of Onchocerca volvulus (Ov) and to develop and configure rapid point of care methods to detect (or sense) these biomarkers.
To produce high-quality chemical hit series with defined, tractable targets as drug leads for tuberculosis.